Ernesto Fazzalari, 46, was captured in the early hours of the morning in an apartment in a remote part of the southern region of Calabria, home to the notorious 'Ndrangheta organised crime syndicate.
Fazzalari was one of the country's most wanted 'Ndrangheta fugitives along with 'superboss' Matteo Messina Denaro.
Ernesto Fazzalari, 46, has been arrested today after two decades on the run, fleeing a life sentence for murder, it has emerged.
On the run since 1996, he was convicted in absentia in 1999 of mafia association, kidnapping, illegal possession of weapons and a double homicide linked to a bloody 1989-91 feud which left 32 people dead in his home town of Taurianova.
His arrest was hailed by the government as a significant victory for the state in its battle against what is now considered Italy's most powerful mafia group.
'Thank you to the judges and the forces of order. Viva l'Italia,' Prime Minister Matteo Renzi wrote in a tweet.
Interior Minister Angelino Alfano described Fazzalari as 'one of the most important fugitives and a leading underworld figure.'
He added: 'This shows that you cannot run from justice. These are the kind of victories that encourage and support us in the difficult but winnable fight against organised crime.'
Notoriously ruthless, the 'Ndrangheta has surpassed Sicily's Cosa Nostra and the Naples-based Camorra thanks to the wealth it has amassed as the principal importer and wholesaler of cocaine produced in Latin America and smuggled into Europe via north Africa and southern Italy.
That trade is worth billions and previous police operations have indicated that the 'Ndrangheta has well-established links with Colombian producer cartels, Mexican crime gangs and mafia families in New York and other parts of North America.
The organisation is made up of numerous village and family-based clans based in Calabria, the rural, mountainous and under-developed 'toe' of Italy's boot.
Fazzalari was captured in the early hours of the morning in an apartment in a remote part of the southern region of Calabria, home to the notorious 'Ndrangheta organised crime syndicate. (file picture of Calabria)
A series of arrests in late 2014 and early 2015 confirmed that the organisation had expanded its Italian operations outside Calabria by buying up dozens of legitimate business across the wealthier north of the country, largely to launder cocaine profits.
Those arrests also providing an unprecedented glimpse into the group's shadowy culture with police secretly filming a quasi-religious initiation ceremony in which new 'wise brothers' swear an 'oath of poison' in which they vow to kill themselves rather than betray a fellow clan member.
There are dozens of 'NDrangheta fugitives still at large despite regular arrests in Italy and around the world.
One alleged don, Rocco Zito, 87, was shot dead in Canada in January, Switzerland arrested 15 convicted 'Ndrangheta fugitives in March and last month the owner of a popular pizzeria in the Dutch seaside town of Scheveningen was unmasked as convicted Calabrian drugs smuggler Rocco Gasperini, 73.
Two mobsters who stayed in their homeland were arrested in January 'living like animals' in a Calabrian mountain bunker with a cache of sub-machine guns, rifles and pistols.
Giuseppe Ferraro and Giuseppe Crea were hiding from gangster enemies as well as the authorities.
In 2013 one of their associates, Francesco Raccosta, was killed by being fed alive to hungry pigs in revenge for his assassination of a rival boss.
Ernesto Fazzalari, 46, was captured in a remote region of Calabria in Italy
The area is home to the notorious 'Ndrangheta organised crime syndicate
He had been on the run since 1996 and faces a life sentence for murder
Convicted of kidnapping and murder linked to a feud in his home town
By JULIAN ROBINSON FOR MAILONLINE and AFP
PUBLISHED: 07:58 EST, 26 June 2016 | UPDATED: 10:36 EST, 26 June 2016